Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database.
Rashmi DhitalSijan BasnetPrakash PaudelYam Prasad AcharyaDilli Ram PoudelPublished in: Journal of community hospital internal medicine perspectives (2018)
Rheumatoid arthritis (RA) is being increasingly recognized as an important contributor to chronic obstructive pulmonary disease (COPD). Although smoking is a major risk factor, other factors may play a role. We used National Inpatient Sample (NIS) from 2013 to explore this relationship. We used propensity matching with a 1:3 nearest-neighbor-matching algorithm to match 1 RA hospitalization to 3 age- and-sex-matched comparators. In the age- and-sex-matched population, RA had a higher odds of COPD (OR 1.20, 95% CI: 1.17-1.22, p < 0.0001). RA is associated with increased COPD prevalence, independent of smoking. COPD might fall within the spectrum of RA complications, likely due to autoimmune and inflammatory mechanisms.
Keyphrases
- chronic obstructive pulmonary disease
- rheumatoid arthritis
- disease activity
- lung function
- risk factors
- ankylosing spondylitis
- interstitial lung disease
- systemic lupus erythematosus
- quality improvement
- machine learning
- smoking cessation
- air pollution
- multiple sclerosis
- oxidative stress
- emergency department
- systemic sclerosis
- deep learning
- adverse drug
- idiopathic pulmonary fibrosis