Login / Signup

Difficult Therapeutic Decisions in Gorham-Stout Disease-Case Report and Review of the Literature.

Katarzyna Wojciechowska-DurczyńskaArkadiusz ZygmuntMarta MikulakMarta LudwisiakAndrzej Lewiński
Published in: International journal of environmental research and public health (2022)
Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.
Keyphrases
  • case report
  • healthcare
  • signaling pathway
  • combination therapy
  • cell free