Left Ventricular Electromechanical Remodeling Detected by Acoustic Cardiography in Paroxysmal Atrial Fibrillation.
Kuo-Li PanShih-Lin ChangYenn-Jiang LinLi-Wei LoYu-Feng HuFa-Po ChungTze-Fan ChaoJo-Nan LiaoChin-Yu LinChung-Hsing LinAbigail Louise D TeShinya YamadaYao-Ting ChangShih-Ann ChenPublished in: Journal of cardiovascular translational research (2020)
This study aimed to investigate the electromechanical function detected by acoustic cardiography before and after radiofrequency ablation therapy (RFA) in paroxysmal AF (PAF) patients with preserved left ventricular ejection fraction (LVEF). Seventy-five symptomatic PAF patients and 69 patients without arrhythmia were enrolled. Thirty-seven PAF patients received RFA therapy. Acoustic cardiographic exam was performed to check S3 and S4 heart sound, electromechanical activation time (EMAT), LV systolic time percentage (LVST), and systolic dysfunction index (SDI) in all participants. Furthermore, 37 PAF patients also received follow-up acoustic cardiography postRFA. PAF had impaired electromechanical systolic function compared with health participants (%EMAT 14.69 ± 3.62 vs. 10.84 ± 2.62; %LVST 40.83 ± 5.14 vs. 36.70 ± 3.87; SDI 4.75 ± 1.61 vs. 3.26 ± 0.96 all p < 0.001). RFA can improve electromechanical systolic function. Improvement below 13.1% could predict the recurrent AF postcatheter ablation. Higher degree of improved electromechanical systolic function postRFA contribute to lower recurrence of AF. Graphical Abstract Receiver operating characteristic (ROC) curve analysis for % change of systolic dysfunction index (SDI) postRFA in the detection of recurrent AF.
Keyphrases
- ejection fraction
- left ventricular
- atrial fibrillation
- heart failure
- end stage renal disease
- blood pressure
- radiofrequency ablation
- aortic stenosis
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- public health
- mesenchymal stem cells
- healthcare
- oxidative stress
- coronary artery disease
- patient reported outcomes
- mitral valve
- mental health
- stem cells
- oral anticoagulants
- left atrial appendage
- percutaneous coronary intervention
- real time pcr
- label free