Marginal zone B cells produce 'natural' atheroprotective IgM antibodies in a T cell-dependent manner.
James HarrisonStephen A NewlandWei JiangDespoina GiakomidiXiaohui ZhaoMarc ClementLeanne MastersAndrej CorovicXian ZhangFabrizio DragoMarcella MaMaria Ozsvar KozmaFroher YasinYuta SaadyHema KothariTian X ZhaoGuo Ping ShiColeen A McNamaraChristoph J BinderAndrew P SageJason M TarkinZiad MallatMeritxell NusPublished in: Cardiovascular research (2024)
Our findings reveal a previously unsuspected role of MZB cells in regulating atheroprotective 'natural' IgM antibody production in a Tfh-dependent manner, which could have important pathophysiological and therapeutic implications.