Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection.

Laura CookMay Q WongWilliam D ReesAlana SchickDaniel J LiskoGenelle R LunkenXiaojiao WangHannah PetersLaura OliveiraTorey LauRegan MahBrian BresslerMegan K LevingsTheodore S Steiner

Published in: Inflammatory bowel diseases (2023)

These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a rationale for C. difficile testing in IBD patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
clinical trial
escherichia coli
oxidative stress
machine learning
artificial intelligence
deep learning
big data
electronic health record
ulcerative colitis