The discovery and development of mRNA vaccines for the prevention of SARS-CoV-2 infection.

Vivian Weiwen Xue Sze Chuen Cesar WongBo LiWilliam Chi Shing Cho

Published in: Expert opinion on drug discovery (2023)

Therapeutic mRNA molecules have plenty of advantages, including flexible design, rapid production, sufficient immune activation, safety without the risk of genome insertion in the host cells, and no viral vectors or particles involved, making them an important tool to fight diseases in the future. However, the application of COVID-19 mRNA vaccines also faces many challenges, such as storage and transportation, mass production, and nonspecific immunity.

Keyphrases

sars cov
induced apoptosis
coronavirus disease
binding protein
cell cycle arrest
respiratory syndrome coronavirus
small molecule
current status
cell death
endoplasmic reticulum stress
genome wide
signaling pathway
gene expression
single cell