Intrinsic cancer cell phosphoinositide 3-kinase δ regulates fibrosis and vascular development in cholangiocarcinoma.

Vanessa Bou MalhamNassima BenzoubirJavier VaqueroChristophe DesterkeJean AgnettiPei Xuan SongEster Gonzalez-SanchezAnder ArbelaizSophie JacquesEmanuel Di ValentinSouad RahmouniTuan Zea TanDidier SamuelJean Paul ThieryMylène Sebagh Laura Fouassier Ama Gassama-Diagne

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Overall, our results support the critical role of PI3Kδ in the progression and aggressiveness of CCA via TGFβ/src/Notch-dependent mechanisms and open new directions for the classification and treatment of CCA patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
machine learning
minimally invasive
prognostic factors
deep learning
cell proliferation
patient reported