IL-4/IL-13 polarization of macrophages enhances Ebola virus glycoprotein-dependent infection.
Kai J RogersBethany BruntonLaura MallingerDana BohanKristina M SevcikJing ChenNatalie RuggioWendy J MauryPublished in: PLoS neglected tropical diseases (2019)
These studies highlight the ability of macrophage polarization to influence EBOV GP-dependent virus replication in vivo and ex vivo, with M2a polarization upregulating cell surface receptor expression and thereby enhancing virus replication. Our findings provide an increased understanding of the host factors in macrophages governing susceptibility to filoviruses and identify novel murine receptors mediating EBOV entry.
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