SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma.

Wenying ChenFengting HuangJing HuangYuanhua LiJuanfei PengYanyan ZhuangXianxian HuangLiting LuZhe ZhuShineng Zhang

Published in: The journal of gene medicine (2021)

The present study found that SLC45A4 prevents autophagy via AMPK/ULK1 axis in TP53 mutant PDA, which may be a promising biomarker and therapeutic target in TP53 mutant PDA.

Keyphrases

wild type
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
skeletal muscle
diabetic rats
mouse model
protein kinase
stress induced