A computerized volumetric segmentation method applicable to multi-centre MRI data to support computer-aided breast tissue analysis, density assessment and lesion localization.
Gokhan ErtasSimon J DoranMartin O LeachPublished in: Medical & biological engineering & computing (2016)
Density assessment and lesion localization in breast MRI require accurate segmentation of breast tissues. A fast, computerized algorithm for volumetric breast segmentation, suitable for multi-centre data, has been developed, employing 3D bias-corrected fuzzy c-means clustering and morphological operations. The full breast extent is determined on T1-weighted images without prior information concerning breast anatomy. Left and right breasts are identified separately using automatic detection of the midsternum. Statistical analysis of breast volumes from eighty-two women scanned in a UK multi-centre study of MRI screening shows that the segmentation algorithm performs well when compared with manually corrected segmentation, with high relative overlap (RO), high true-positive volume fraction (TPVF) and low false-positive volume fraction (FPVF), and has an overall performance of RO 0.94 ± 0.05, TPVF 0.97 ± 0.03 and FPVF 0.04 ± 0.06, respectively (training: 0.93 ± 0.05, 0.97 ± 0.03 and 0.04 ± 0.06; test: 0.94 ± 0.05, 0.98 ± 0.02 and 0.05 ± 0.07).
Keyphrases
- deep learning
- convolutional neural network
- contrast enhanced
- magnetic resonance imaging
- machine learning
- artificial intelligence
- metabolic syndrome
- computed tomography
- diffusion weighted imaging
- high resolution
- mass spectrometry
- pregnant women
- neural network
- single cell
- social media
- clinical decision support
- adipose tissue
- network analysis
- real time pcr