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GATA-3 in T-cell lymphoproliferative disorders.

Carlos Murga-ZamalloaRyan A Wilcox
Published in: IUBMB life (2019)
GATA-3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA-3 in the pathogenesis of molecularly, genetically, and clinically distinct T-cell lymphoproliferative disorders, but also have significant diagnostic, prognostic, and therapeutic implications.
Keyphrases
  • transcription factor
  • epstein barr virus
  • signaling pathway
  • diffuse large b cell lymphoma
  • free survival
  • chemotherapy induced