Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.
Jianxin ShiXing HuaBin ZhuSarangan RavichandranMingyi WangCu NguyenSeth A BrodieAlessandro PalleschiMarco AlloisioGianluca PariscentiKristine JonesWeiyin ZhouAaron J BoukJoseph BolandBelynda D HicksAdam RischHunter BennettBrian T LukeLei SongJubao DuanPengyuan LiuTakashi KohnoQingrong ChenDaoud MeerzamanCrystal MarconettIte A OffringaIan MillsNeil E CaporasoMitchell H GailAngela C PesatoriDario ConsonniPier Alberto BertazziStephen J ChanockMaria Teresa LandiPublished in: PLoS medicine (2016)
These data provide a genomic characterization of LUAD pathogenesis and progression. The distinct clonal and subclonal mutation signatures suggest possible diverse carcinogenesis pathways for endogenous and exogenous exposures, and may serve as a foundation for more effective treatments for this lethal disease. LUAD's high heterogeneity emphasizes the need to further study this tumor type and to associate genomic findings with clinical outcomes.