Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex.
Marie-Paule E van EngelenSander C J VerfaillieAnnemieke DolsMardien L OudegaRonald BoellaardSandeep S V GollaMarijke den HollanderRik OssenkoppelePhilip ScheltensBart N M van BerckelYolande A L PijnenburgEverard G B VijverbergPublished in: EJNMMI research (2023)
Our findings indicate subtle but distinct metabolic patterns in bvFTD and PPD, most strongly in the dACC. The degree of frontotemporal and cingulate hypometabolism was related to impaired social cognition, compulsiveness and executive dysfunctioning. Our findings suggest that the dACC might be an important region to differentiate between bvFTD and PPD but needs further validation.