Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca2+ uptake and suppress cardiac arrhythmogenesis.

Paulina SanderMichael FengMaria K SchweitzerFabiola WiltingSophie M GutenthalerDaniela M ArduinoSandra FischbachLisa DreizehnterAlessandra MorettiThomas Gudermann Fabiana Perocchi Johann Schredelseker

Published in: British journal of pharmacology (2021)

Taken together we identified ezetimibe and disulfiram as novel MiCUps and efficient suppressors of arrhythmogenesis and as such as, promising candidates for future preclinical and clinical studies.

Keyphrases

oxidative stress
current status
left ventricular
cell therapy
drug administration
protein kinase
heart failure
drug induced
bone marrow