STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model.
Shuhei KiiHidemitsu KitamuraShinichi HashimotoKazuho IkeoNobuki IchikawaTadashi YoshidaShigenori HommaMishie TaninoAkinobu TaketomiPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)
Two different types of Ly6c-expressing macrophages are induced in the inflamed tissues through the IFN-α/β-STAT1-mediated CCL2/CCR2 cascade and this is associated with the pathogenesis such as onset, exacerbation, and subsequent chronicity of acute colitis.
Keyphrases
- drug induced
- liver failure
- respiratory failure
- liver injury
- dendritic cells
- cell proliferation
- chronic obstructive pulmonary disease
- aortic dissection
- gene expression
- immune response
- high glucose
- hepatitis b virus
- extracorporeal membrane oxygenation
- diabetic rats
- regulatory t cells
- oxidative stress
- liver fibrosis
- intensive care unit