Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis.

Nittaya KhakhumPreeti BharajJulia N MyersDaniel TapiaDavid H WalkerJanice J EndsleyAlfredo G Torres

Published in: PLoS neglected tropical diseases (2019)

Our data indicate that CLH001 serves as an effective live attenuated vaccine to prevent glanders and melioidosis. The quantity and quality of antibody responses as well as improving cell-mediated immune responses following vaccination need to be further investigated prior to advancement to preclinical studies.

Keyphrases

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