Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Matthieu JabaudonRaiko BlondonnetBruno PereiraRodrigo Cartin-CebaChristoph LichtensternTommaso MauriRogier M DetermannTomas DrabekRolf D HubmayrOgnjen GajicFlorian UhleAndrea CoppadoroAntonio PesentiMarcus J SchultzMarco V RanieriHelena BrodskaSégolène MrozekVincent SapinMichael A MatthayJean-Michel ConstantinCarolyn S Calfee

Published in: Intensive care medicine (2018)

Higher baseline plasma sRAGE was associated with higher 90-day mortality in patients with ARDS, independently of driving pressure and tidal volume, thus reinforcing the likely contribution of alveolar epithelial injury as an important prognostic factor in ARDS. Registration: PROSPERO (ID: CRD42018100241).

Keyphrases

acute respiratory distress syndrome
prognostic factors
extracorporeal membrane oxygenation
mechanical ventilation
cardiovascular events
risk factors
case report
electronic health record
big data
cardiovascular disease
type diabetes
carbon dioxide
machine learning
deep learning
cone beam