In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia.

Ahmed M Mansour Rabaa M Khaled Krzysztof RadackiZeina YounesMariam GamalBeatrice GuirguisGamal A E MostafaEssam A AliOla R Shehab

Published in: Dalton transactions (Cambridge, England : 2003) (2023)

Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(I) and Ru(II) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(II) complex (IC 50 = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(I) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

Keyphrases

induced apoptosis
bone marrow
cell cycle arrest
endothelial cells
liver failure
endoplasmic reticulum stress
oxidative stress
energy transfer
metal organic framework
cell death
transition metal
respiratory failure
hepatitis b virus
cell proliferation
induced pluripotent stem cells
quantum dots