Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood-tests during long-term treatment: cohort study using data from Clinical Practice Research Datalink Gold and Aurum.

Georgina NakaferoMatthew J GraingeTim CardMaarten W TaalGuruprasad P AithalWeiya ZhangMichael DohertyChristopher P FoxChristian D MallenAbhishek Abhishek

Published in: Rheumatology (Oxford, England) (2021)

We have developed and externally validated an easy-to-use prognostic model that may be used to risk-stratify monitoring for leflunomide toxicity and to make informed choices about risks when choosing treatments.

Keyphrases

clinical practice
oxidative stress
electronic health record
big data
human health
risk assessment