Identification of the histidine-rich glycoprotein domains responsible for contact pathway inhibition.
Tammy K TruongRida A MalikXintong YaoJames Charles FredenburghAlan R StaffordHasam M MadaratiColin A KretzJeffrey I WeitzPublished in: Journal of thrombosis and haemostasis : JTH (2022)
The interaction of HRG with FXIIa and polyP is predominantly mediated by the HRR domain. Like intact HRG, HRR downregulates the contact pathway and contributes to HRG-mediated down regulation of coagulation.
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