Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.

Haijun LiuShencun FangWei WangYusi ChengYingming ZhangHong LiaoHonghong YaoJie Chao

Published in: Particle and fibre toxicology (2016)

Our results elucidated a link between SiO2-induced fibrosis and MCPIP1/p53 signaling-mediated autophagy. These findings provide novel insight into the potential targeting of MCPIP1 or autophagy in the development of potential therapeutic strategies for silicosis.

Keyphrases

pulmonary fibrosis
cell death
endoplasmic reticulum stress
oxidative stress
diabetic rats
signaling pathway
high glucose
adipose tissue
human health
risk assessment
cancer therapy
drug delivery