Computational reassessment of RNA-seq data reveals key genes in active tuberculosis.

Rakesh AryaHemlata ShakyaReetika ChaurasiaSurendra KumarJoseph M VinetzJong Joo Kim

Published in: PloS one (2024)

The study presents valuable insights into the critical gene network perturbed during tuberculosis. These genes are determinants for assessing the effectiveness of an anti-TB response and distinguishing between active TB and healthy individuals. GBP5, IFITM3 and EPSTI1 emerged as candidate core genes in TB and holds potential as novel molecular targets for the development of interventions in the treatment of TB.

Keyphrases

mycobacterium tuberculosis
rna seq
genome wide
genome wide identification
single cell
pulmonary tuberculosis
bioinformatics analysis
genome wide analysis
physical activity
dna methylation
copy number
electronic health record
emergency department
gene expression
climate change
machine learning