Determination of the Diagnostic Performance of Laboratory Tests in the Absence of a Perfect Reference Standard: The Case of SARS-CoV-2 Tests.
Sonja HartnackHenning NiliusSabrina JegerlehnerFranziska Suter-RinikerPascal BittelPhilipp JentMichael NaglerPublished in: Diagnostics (Basel, Switzerland) (2023)
Applying the BLCM, the diagnostic accuracy of RT-PCR was high but not perfect. In contrast to previous results, the sensitivity of the antigen test was higher. Our results suggest that BLCMs are valuable tools for investigating the diagnostic performance of laboratory tests in the absence of perfect reference standard.