Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition.

Charlotte Harken JensenRikke Helin JohnsenTilde EskildsenChristina BaunDitte Gry EllmanShu FangSara Thornby BakSvend HvidstenLars Allan LarsenAnn Mari RosagerLars Peter RiberMikael SchneiderJo De MeyMads ThomassenMark BurtonShizuka UchidaJorge LabordaDitte Caroline Andersen

Published in: Clinical and translational medicine (2024)

Our results suggest that pericardial Dlk1 embraces a, so far, unnoticed role in the heart augmenting cardiac fibrosis through EMT. Monitoring DLK1 levels as well as targeting pericardial DLK1 may thus offer new venues for cardio-protection.

Keyphrases

heart failure
atrial fibrillation
left ventricular
cell proliferation
liver fibrosis
drug delivery
signaling pathway