Heptaellipside A, a rare new 2,28-bidesmosidic lupane-type saponin from the leaves of Heptapleurum ellipticum .

For the first time, phytochemical constituents of the leaves of Heptapleurum ellipticum were investigated. One rare new 2,28-bidesmosidic lupane-type saponin, named heptaellipside A ( 1 ), along with four other lupane-type analogs ( 2-5 ) were purified by combining differently chromatographic methods. All of the separated compounds ( 1-5 ) were communicated for the first time from H. ellipticum . The structures of them were definitely illustrated following extensive and comprehensive UV/VIS, FTIR, HRMS/ESI, and NMR techniques. Further, all isolated compounds were evaluated for their α -glucosidase and α -amylase inhibition. As the results, compound 3 respectively exhibited stronger in both inhibitory activities against α -glucosidase and α -amylase (IC 50 values of 15.53 and 26.93 μM), than the acarbose standard (IC 50 values of 214.50 and 143.48 μM).