Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles.
Huahua JiangYaxin GuoLixue ChenHuifeng ShiNing HuangHongbin ChiRui YangXiaoyu LongJie QiaoPublished in: Journal of clinical medicine (2023)
Polycystic ovary syndrome (PCOS) can induce fertility and metabolism disorders, which may increase the prevalence of glucose metabolism disorders and cause health hazards to women and their offspring. We aim to evaluate the effect of maternal preconception glucose metabolism on neonatal birthweight in PCOS women undergoing IVF/ICSI cycles. We retrospectively analyzed 269 PCOS women who delivered 190 singletons and 79 twins via IVF/ICSI at a reproductive center. The effects of maternal preconception glucose metabolism indicators on singleton and twin birthweight were evaluated using generalized linear models and generalized estimate equations, respectively. The potential nonlinear associations were evaluated using generalized additive models. The analyses were further stratified by maternal preconception BMI and delivery mode to evaluate the possible interaction effects. Among PCOS women, maternal preconception fasting plasma glucose (FPG) and glycohemoglobin (HbA1c) had significant negative associations with singleton birthweight (all p for trends = 0.04). We also found an overweight-specific association between elevated maternal preconception 2 h plasma insulin (2hPI) and twin birthweight ( p for interactions = 0.05) and a caesarean-specific association between maternal preconception HbA1c and singleton birthweight ( p for interactions = 0.02) in PCOS women. Maternal preconception glucose metabolism may affect neonatal birthweight, suggesting the importance of preconception glucose and insulin management for PCOS women. Further large prospective cohorts and animal studies are needed to confirm these findings and investigate the potential mechanisms.
Keyphrases
- polycystic ovary syndrome
- birth weight
- gestational age
- pregnancy outcomes
- insulin resistance
- preterm birth
- weight gain
- pregnant women
- type diabetes
- adipose tissue
- skeletal muscle
- high fat diet
- healthcare
- blood glucose
- risk factors
- health information
- risk assessment
- blood pressure
- body mass index
- physical activity
- preterm infants
- young adults
- public health
- social media
- human health