A hSCARB2-transgenic mouse model for Coxsackievirus A16 pathogenesis.

Yanli ChenHeng LiJinxi YangHuiwen ZhengLei GuoWeiyu LiZening YangJie SongLongding Liu

Published in: Virology journal (2021)

The hSCARB2-transgenic mice can be productively infected with CA16 via respiratory route and exhibited a clear tropism to lung and brain tissues, which can serve as a model to investigate the pathogenesis of CA16 associated respiratory and neurological disease.

Keyphrases

mouse model
gene expression
cerebral ischemia
respiratory tract
white matter
resting state
multiple sclerosis
functional connectivity
blood brain barrier
brain injury