Login / Signup

Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity.

Kathleen LaRow BrownVijendra RamlallMichael ZietzUndina GisladottirNicholas P Tatonetti
Published in: Nature communications (2024)
SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While genetic studies can highlight potential drug targets, understanding the heritability of SARS-CoV-2 susceptibility and COVID-19 severity can contextualize their results. To date, loci from meta-analyses explain 1.2% and 5.8% of variation in susceptibility and severity respectively. Here we estimate the importance of shared environment and additive genetic variation to SARS-CoV-2 susceptibility and COVID-19 severity using pedigree data, PCR results, and hospitalization information. The relative importance of genetics and shared environment for susceptibility shifted during the study, with heritability ranging from 33% (95% CI: 20%-46%) to 70% (95% CI: 63%-74%). Heritability was greater for days hospitalized with COVID-19 (41%, 95% CI: 33%-57%) compared to shared environment (33%, 95% CI: 24%-38%). While our estimates suggest these genetic architectures are not fully understood, the shift in susceptibility estimates highlights the challenge of estimation during a pandemic, given environmental fluctuations and vaccine introduction.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • coronavirus disease
  • genome wide
  • meta analyses
  • healthcare
  • copy number
  • risk assessment
  • machine learning
  • life cycle