Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner.

J H ParkYoon Jung ParkM ChoJ LimA M LindrothY J Park

Published in: International journal of obesity (2005) (2017)

Our findings demonstrate that male founder obesity influences impaired glucose regulation in F2 progeny possibly via ER stress in a sex-specific manner and it is, in part, contributed by altered DNA methylation at the Nr1h3 locus.

Keyphrases

endoplasmic reticulum stress
insulin resistance
dna methylation
metabolic syndrome
weight loss
induced apoptosis
high fat diet induced
type diabetes
weight gain
high fat diet
gene expression
genome wide
adipose tissue
blood glucose
body mass index
oxidative stress
glycemic control
genome wide association study