Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.

Yifeng ZhengNeng WangShengqi WangJuping ZhangBowen YangZhiyu Wang

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our findings shed new light on the association between chronic psychological stress and splenic MDSC mobilization, and suggest that stress-related glucocorticoid elevation can enhance TAM/CXCL1 signaling and subsequently recruit splenic MDSCs to promote PMN formation via CXCR2.

Keyphrases

squamous cell carcinoma
small cell lung cancer
stress induced
drug induced
sleep quality
heat stress
depressive symptoms
physical activity
young adults