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Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis.

Mattia RossoCindy T GonzalezBrian C HealyShrishti SaxenaAnu PaulKjetil BjornevikJens KuhlePascal BenkertDavid LeppertCharles GuttmannRohit BakshiHoward L WeinerTanuja Chitinis
Published in: Annals of clinical and translational neurology (2020)
Our findings support sNfL as a marker of clinical relapses and Gd+ lesions. sNfL peaks in a 3-month window around Gd+ lesions. sNfL shows promise as a biomarker of neurological inflammation and possibly of simultaneous Gd+ lesions during a clinical relapse.
Keyphrases
  • multiple sclerosis
  • oxidative stress
  • machine learning
  • brain injury