Inflammation-induced left ventricular fibrosis is partially mediated by tumor necrosis factor-α.
Ashmeetha ManilallLebogang MokotediSulè GunterRegina Le RouxSerena FourieColleen A FlanaganAletta M E MillenPublished in: Physiological reports (2022)
Chronic systemic inflammation induces fibrosis and dysregulated LV extracellular matrix remodeling by increasing local cardiac pro-fibrotic gene expression, which is partially mediated by TNF-α. Inflammation-induced LV diastolic dysfunction is likely independent of myocardial fibrosis.
Keyphrases
- left ventricular
- extracellular matrix
- oxidative stress
- gene expression
- diabetic rats
- high glucose
- rheumatoid arthritis
- drug induced
- hypertrophic cardiomyopathy
- heart failure
- acute myocardial infarction
- mitral valve
- cardiac resynchronization therapy
- dna methylation
- blood pressure
- systemic sclerosis
- liver fibrosis
- endothelial cells
- anti inflammatory
- atrial fibrillation
- ejection fraction
- percutaneous coronary intervention