Sex-specific associations of matrix metalloproteinases in Alzheimer's disease.
Mari AksnesTrine H EdwinIngvild SaltvedtRannveig S EldholmFarrukh A ChaudhryNathalie B HalaasMarius MyrstadLeiv O WatneAnne-Brita KnapskogPublished in: Biology of sex differences (2023)
Our results support the use of MMPs/TIMPs as markers of sex differences and progression in AD. Our findings show sex-specific effects of MMP-3 and TIMP-4 on amyloid pathology. Further, this study highlights that the sex-specific effects of MMP-10 on cognitive and functional decline should be studied further if MMP-10 is to be used as a prognostic biomarker for AD.
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