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HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies.

Natasha TraceyHelen CreedonAlain J KempJayne CulleyMorwenna MuirTeresa KlinowskaValerie G Brunton
Published in: Breast cancer research and treatment (2019)
Together these data indicate a role for HO-1-induced autophagy in resistance to pan-HER family kinase inhibitors.
Keyphrases
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • pi k akt
  • high glucose
  • electronic health record
  • big data
  • cell proliferation
  • machine learning
  • stress induced