Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits.
Pauline MaillardHanzhang LuKonstantinos ArfanakisBrian T GoldChristopher E BauerValentinos ZachariouLara StablesDanny J J WangKay JannSudha SeshadriMarco DueringLaura J HillmerGary A RosenbergHaykel SnoussiFarshid SepehrbandMohamad HabesBaljeet SinghJoel H KramerRoderick A CorriveauHerpreet SinghKristin SchwabKarl G HelmerSteven M GreenbergArvind CaprihanCharles DeCarliClaudia L Satizabalnull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2022)
The three biomarker kits demonstrated very high inter-rater reliability, test-retest repeatability, and inter-scanner reproducibility, offering robust biomarkers suitable for future multi-site observational studies and clinical trials in the context of vascular cognitive impairment and dementia (VCID).