Pulmonary IL-33 orchestrates innate immune cells to mediate respiratory syncytial virus-evoked airway hyperreactivity and eosinophilia.

Yi-Hsiu WuAlan Chuan-Ying LaiPo-Yu ChiChristina Li-Ping ThioWei-Yu ChenChing-Hui Tsai Yungling Leo LeeNicholas W LukacsYa-Jen Chang

Published in: Allergy (2019)

This study highlights the importance of IL-33-activated ILC2s in mediating RSV-triggered AHR and eosinophilia. In addition, IL-33 signaling in myeloid cells is crucial for airway inflammation.

Keyphrases

respiratory syncytial virus
immune response
induced apoptosis
pulmonary hypertension
dendritic cells
acute myeloid leukemia
cell cycle arrest
oxidative stress
cell death