Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis.
Elena AndreucciFrancesca MargheriSilvia PeppicelliFrancesca BianchiniJessica RuzzoliniAnna LaurenzanaGabriella FibbiCosimo BruniSilvia Bellando-RandoneSerena GuiducciEloisa RomanoMirko ManettiMarco Matucci-CerinicLido CaloriniPublished in: Rheumatology (Oxford, England) (2021)
This study showed the relationship of the metabolic reprogramming of SSc dermal fibroblasts, extracellular acidosis and endothelial dysfunction that may contribute to the impairment and loss of peripheral capillary networks in SSc disease.