Non-invasive and time-resolved measurement of the respiration activity of Chinese hamster ovary cells enables prediction of key culture parameters in shake flasks.

Nina IhlingLara Pauline MunklerRichard PaulChristoph BergBritta ReichenbächerMarvin KadischDietmar LangJochen Büchs

Published in: Biotechnology journal (2022)

Taken together, non-invasive measurement of the respiration activity enabled time-resolved determination of key culture parameters for increased process understanding in shake flasks.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
signaling pathway
solid phase extraction
pi k akt