Pannexin 1 Differentially Affects Neural Precursor Cell Maintenance in the Ventricular Zone and Peri-Infarct Cortex.
Leigh E Wicki-StordeurJuan C Sanchez-AriasJagroop DhaliwalEsther O Carmona-WagnerValery I ShestopalovDiane C LagaceLeigh Anne SwaynePublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Here, we demonstrate that Pannexin 1 (Panx1) maintains a consistent population size of neural precursor cells in the ventricular zone, both in the healthy brain and in the context of stroke. In contrast, Panx1 appears to be detrimental to the survival of neural precursor cells that surround damaged cortical tissue in the stroke brain. This suggests that targeting Panx1 in the peri-infarct cortex, in combination with other therapies, could improve cell survival around the injury site.
Keyphrases
- induced apoptosis
- functional connectivity
- resting state
- cell cycle arrest
- atrial fibrillation
- heart failure
- white matter
- acute myocardial infarction
- magnetic resonance
- left ventricular
- oxidative stress
- computed tomography
- stem cells
- single cell
- cell death
- cell therapy
- signaling pathway
- acute coronary syndrome
- cancer therapy
- cell proliferation
- coronary artery disease
- drug delivery
- percutaneous coronary intervention
- free survival
- pi k akt