Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response.

Jessica P RoelandsWouter HendrickxGabriele ZoppoliRaghvendra MallMohamad SaadKyle HalliwillGiuseppe CuriglianoDarawan RinchaiJulie DecockLucia G DeloguTolga TuranJosue SamayoaLotfi ChouchaneAlberto BallestreroEna WangPascal FinettiFrancois BertucciLance D MillerJerome GalonFrancesco M MarincolaPeter J K KuppenMichele CeccarelliDavide Bedognetti

Published in: Journal for immunotherapy of cancer (2021)

This is the first systematic study demonstrating that the prognostic and predictive role of a bona fide favorable intratumoral immune response is dependent on the disposition of specific oncogenic pathways. This information could be used to refine stratification algorithms and prioritize hierarchically relevant targets for combination therapies.

Keyphrases

immune response
transcription factor
machine learning
dendritic cells
toll like receptor
deep learning
healthcare
health information
inflammatory response
social media