Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study.
Junxi LiuRebecca C RichmondJack BowdenCiarrah BarryHassan S DashtiIyas DaghlasJacqueline M LaneSamuel E JonesAndrew R WoodTimothy M FraylingAlison K WrightMatthew J CarrSimon G AndersonRichard A EmsleyDavid W RayMichael N WeedonRicha SaxenaDeborah A LawlorMartin K RutterPublished in: Diabetes care (2022)
Our results suggest that frequent insomnia symptoms cause higher HbA1c levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes.