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PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors.

Minsuk KwonChang Gon KimHoyoung LeeHyunsoo ChoYoungun KimEung Chang LeeSeong Jin ChoiJung-Yun LeeIn-Ho SeoBjarne BogenIk-Chan SongDeog-Yeon JoJin Seok KimSu-Hyung ParkInhak ChoiYoon Seok ChoiEui-Cheol Shin
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our findings indicate that combined blockade of PD-1 and TGFβ may be useful for the treatment of multiple myeloma.
Keyphrases
  • multiple myeloma
  • bone marrow
  • transforming growth factor
  • mesenchymal stem cells
  • epithelial mesenchymal transition
  • combination therapy
  • replacement therapy