Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis.

Cheng DingChuang YangTao ChengXingyan WangQiaojie WangRenke HeShang SangKechao ZhuDongdong XuJiaxing WangXijian LiuXianlong Zhang

Published in: Journal of nanobiotechnology (2021)

Our findings suggest that M-Se@SiO2 have an immunomodulatory role in LPS-induced inflammation and bone remodeling, which demonstrates that M-Se@SiO2 are a promising engineered nanoplatform for the treatment of osteolysis occurring after arthroplasty.

Keyphrases

lps induced
inflammatory response
oxidative stress
magnetic nanoparticles
photodynamic therapy
adipose tissue
cancer therapy
bone mineral density
tissue engineering
combination therapy
reduced graphene oxide
bone loss
bone regeneration
gold nanoparticles
highly efficient