Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCAD Database.
Fang-Shu OuDaniel H AhnJesse G DixonAxel GrotheyYiyue LouPashtoon Murtaza KasiJoleen M HubbardEric Van CutsemLeonard B SaltzHans-Joachim SchmollRichard M GoldbergAlan P VenookPaulo HoffJean-Yves DouillardJ Randolph HechtHerbert HurwitzCornelis J A PuntMiriam KoopmanCarsten BokemeyerCharles S FuchsEduardo Diaz-RubioNiall C TebbuttChiara CremoliniFairooz F KabbinavarTanios Bekaii-SaabBenoist ChibaudelTakayuki YoshinoZalcberg JohnRichard A AdamsAimery de GramontQian ShiPublished in: Cancers (2023)
Varied responses at first restaging are common among patients receiving first-line therapy for mCRC. Our lesion-based measurement criteria allowed for better mortality discrimination, which could potentially be informative for treatment decision-making and influence patient outcomes.