Nigrostriatal blood-brain barrier opening in Parkinson's disease.
Carmen Gasca-SalasJosé A Pineda-PardoMarta Del ÁlamoTamara JiménezClara TrompetaGabriella ToltsisLina Garcia-CañamaqueBeatriz Fernández-RodríguezMichele MatarazzoIsabel Plaza de Las HerasElena Natera-VillalbaR Martinez FernandezAlicia DuqueSantiago Ruiz de AguiarJavier BlesaItay RachmilevichJosé A ObesoPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
BBB-O of the nigrostriatal system is a feasible and well-tolerated approach in patients with PD. 18F-Choline-PET uptake indicates penetration into the parenchyma after BBB-O, which suggests that the opening is functionally effective. This minimally invasive technique could facilitate delivery of putative neurorestorative molecules to brain regions vulnerable to neurodegeneration.