Thrombospondin-1 mediates muscle damage in brachio-cervical inflammatory myopathy and systemic sclerosis.

Xavier Suárez-Calvet Jorge Alonso-PérezIvan CastellvíAna Carrasco-RozasEsther Fernández-SimónCarlos ZamoraLaura Martínez-MartínezAlicia Alonso-JiménezRicardo Rojas-GarcíaJoana TurónLuis Antonio Querol-Gutiérrez Noemi de LunaAna Milena-MillanHéctor CorominasDiego CastilloElena Cortés-Vicente Isabel Illa Eduard Gallardo Jordi Díaz-Manera

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

Patients with SSc may present with a clinically and pathologically distinct myopathy. A prompt and correct diagnosis has important implications for treatment. Finally, TSP-1 may participate in the pathologic changes observed in muscle.

Keyphrases

systemic sclerosis
interstitial lung disease
skeletal muscle
late onset
oxidative stress
neoadjuvant chemotherapy
muscular dystrophy
radiation therapy
locally advanced
combination therapy
lymph node
early onset