Polymer-Protein Core-Shell Nanoparticles for Enhanced Antigen Immunogenicity.

Xiaolei ZhangXia ZhaoJittima Amie LuckanagulJing YanYuzhe NieL Andrew LeeQian Wang

Published in: ACS macro letters (2017)

Nanoengineered vaccine platforms can be modeled after viruses and other pathogens with highly organized and repetitive structures that trigger the host immune system. Here we demonstrated a pyridine-grafted poly(ε-caprolactone)-based polymer-protein core-shell nanoparticles (PPCS-NPs) platform can effectively trigger the host immune system and lead to significantly higher antibody titers.

Keyphrases

protein protein
high frequency
high throughput
high resolution
small molecule
gram negative