Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI.
Erwin KrikkenWybe J M van der KempVitaliy KhlebnikovThijs van DalenMaartje LosHanneke W M van LaarhovenPeter R LuijtenMaurice A A J van den BoschDennis W J KlompJannie P WijnenPublished in: NMR in biomedicine (2019)
As differentiation of cancer stages was confirmed by observation of a linear correlation between cell proliferation marker PE/Pi (phosphoethanolamine over inorganic phosphate) and pH in the tumor, our data demonstrates that the concentration of mobile proteins likely supersedes the contribution of the exchange rate to the APT signal.