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Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress.

Kang WangYe WangHua WanJie WangLi HuShuainan HuangMingchen ShengJiayi WuXing HanYoujia YuPeng ChenFeng Chen
Published in: Genes & genomics (2024)
Our study revealed a functional role of ACTN2 under chronic stress, loss of ACTN2 function accelerated H9c2 hypertrophy through ERK signaling. A commercial drug, Ibudilast, was identified to reverse cell hypertrophy in vitro.
Keyphrases
  • signaling pathway
  • single cell
  • cell proliferation
  • pi k akt
  • drug induced
  • cell therapy
  • stress induced
  • stem cells
  • heat stress
  • mesenchymal stem cells
  • emergency department
  • adverse drug