Antipseudomonal activity enhancement of luminescent iridium(iii) dipyridylamine complexes under visible blue light.
E SauvageotMargaux ElieSylvain GaillardRichard DaniellouPierre FechterIsabelle J SchalkV GasserJean-Luc RenaudGaëtan L A MislinPublished in: Metallomics : integrated biometal science (2017)
Cyclometallated iridium(iii) dipyridylamine complexes present antibacterial activity against P. aeruginosa, a highly resistant pathogenic bacterium. This activity is increased when the complex is conjugated to biotin, a bacterial nutrient, and a MIC of 4 μM (4 μg mL-1) has been observed. The irradiation of P. aeruginosa cultures with blue LED light potentiates the anti-bacterial activities of these iridium(iii) complexes when they are conjugated to a glycoside.